Comprehensive preclinical pharmacology and pharmacodynamics evaluation bench & full range of animal models
KCI Biotech is a preclinical CRO specializing in respiratory diseases, providing reliable and reproducible respiratory disease models for preclinical drug development. We help pharmaceutical and biotechnology partners accelerate respiratory drug discovery through rigorous animal model establishment, scientific validation, and integrated respiratory CRO services that cover study design, execution, and data interpretation.
KCI Biotech supports a wide spectrum of respiratory disorders, from acute lung injury to chronic conditions like COPD and idiopathic pulmonary fibrosis (IPF). Multiple species, including mice, rats, hamsters, rabbits, and guinea pigs, are used to ensure translational relevance.
As a respiratory-focused preclinical CRO, KCI Biotech provides a comprehensive range of respiratory disease models covering both acute and chronic conditions.
Our preclinical CRO respiratory disease services cover both acute and chronic models, including but not limited to:
Acute Lung Injury Models (LPS / Bleomycin Induced) — Simulating acute pulmonary inflammation and injury for evaluating anti-inflammatory and protective therapies.
Cough Models (Citric Acid + Histamine Induced in Guinea Pigs) — Designed to assess the efficacy of antitussive and bronchodilator drug candidates.
Chronic Obstructive Pulmonary Disease Models (Smoking + LPS Induced) — Reproducing airway inflammation, emphysematous changes, and lung function decline to support respiratory drug development.
Idiopathic Pulmonary Fibrosis Models (Bleomycin Induced, Unilateral / Bilateral, Single / Repeated Dosing) — Used for studying fibrosis progression, collagen deposition, and evaluating anti-fibrotic agents.
Asthma Models (OVA or Scabies Mite Induced, Acute / Chronic) — Mimicking airway hyperresponsiveness, mucus hypersecretion, and immune cell infiltration for asthma drug evaluation.
Silicosis Models (Silicon Dioxide Induced) — For investigating chronic lung fibrosis and dust-related respiratory disorders.
We work with multiple animal species, including mice, rats, rabbits, guinea pigs, and hamsters, to ensure translational relevance in respiratory drug development.
Our respiratory disease models are developed using scientifically validated induction methods, such as inhalation, intratracheal instillation, or systemic administration of agents like LPS, bleomycin, or OVA. Each model follows standardized SOPs to ensure reproducibility, GLP compliance, and consistent data quality.
Following model establishment, we conduct multi-dimensional assessments that include:
This integrated evaluation framework allows our respiratory diseases CRO team to generate high-quality, interpretable data for decision-making in early drug development.
KCI Biotech is committed to delivering scientific excellence and operational reliability as a trusted respiratory disease contract research organization. Our goal is to accelerate the path from discovery to clinic for innovative respiratory drug development programs.
At KCI Biotech, collaboration is the cornerstone of every project. As a CRO specializing in respiratory disorders, we work closely with pharmaceutical and biotech partners to design customized studies that accelerate respiratory drug development. Our dedicated scientists and technicians ensure that each experimental model and assessment strategy precisely matches the client’s research objectives.
Guided by a commitment to scientific excellence, KCI Biotech’s respiratory CRO services empower researchers to translate preclinical insights into clinical success. By partnering with us, you gain access to a comprehensive suite of respiratory preclinical CRO services, expert consultation, and transparent communication throughout every project phase.
For more information about our respiratory CRO services and how we can support your upcoming studies, please contact us today.
Comprehensive preclinical drug development and service platform
Building A2, No, 8 Yanghua road, Suzhou industrial Park, Suzhou.P.R, china
