Respiratory-Focused Preclinical CRO

KCI Biotech is a preclinical CRO specializing in respiratory diseases, providing reliable and reproducible respiratory disease models for preclinical drug development. We help pharmaceutical and biotechnology partners accelerate respiratory drug discovery through rigorous animal model establishment, scientific validation, and integrated respiratory CRO services that cover study design, execution, and data interpretation.

KCI Biotech supports a wide spectrum of respiratory disorders, from acute lung injury to chronic conditions like COPD and idiopathic pulmonary fibrosis (IPF). Multiple species, including mice, rats, hamsters, rabbits, and guinea pigs, are used to ensure translational relevance.

Why Use Animal Models in Respiratory Research

Because complex pulmonary interactions cannot be fully replicated in vitro, respiratory disease models are necessary to evaluate therapeutic efficacy and understand pathological progression. Working with a dedicated CRO for respiratory diseases provides the objective data required to bridge the gap between preclinical insights and clinical success.

Our Portfolio of Respiratory Disease Models

KCI Biotech provides reproducible in vivo models covering major pulmonary indications. Each model is established using standardized SOPs to ensure consistent data quality:

Acute Lung Injury & Fibrosis Models

We provide validated animal models of acute lung injury along with comprehensive fibrosis systems:

• Lipopolysaccharide (LPS) or bleomycin (BLM)-induced acute lung injury
• Unilateral and bilateral idiopathic pulmonary fibrosis models (single or repeated bleomycin dosing)
• Amiodarone-induced interstitial pulmonary fibrosis model

COPD, Cough & Bronchiectasis Models

Our platform delivers reproducible airway obstruction and inflammatory models:

• Cigarette smoke (CS) and CS + LPS-induced COPD animal model
• Citric acid + histamine-induced and ATP + citric acid-induced cough models in guinea pigs
• Pseudomonas aeruginosa-induced bronchodilatation and COPD combined with bronchiectasis models

Asthma & Dust-Related Disease Models

As an experienced asthma models CRO, we support comprehensive mechanistic evaluations:

• Standard asthma mouse model for acute and chronic assessments (induced by ovalbumin [OVA] or dust mites + LPS)
• Model of scabies mite-induced acute asthma
• Silicon dioxide-induced silicosis model and carbon nanoparticle-induced nodular lung disease model

Comprehensive Solutions & Collaborative Partnership

KCI Biotech delivers integrated preclinical solutions to streamline pulmonary research:

Disease Portfolio: Our respiratory diseases CRO platform encompasses a variety of specific respiratory models within a broader catalog of over 500 validated disease models.

Evaluation Platforms: Our multi-dimensional framework includes pulmonary function testing, BALF cytology, micro-CT imaging, and biomarker quantification.

Execution & Capacity: Conducts GLP-compliant studies within AAALAC-accredited facilities. With 1,000+ global partnerships, we provide comprehensive respiratory preclinical CRO services, ensuring seamless execution from selection to data interpretation.

Collaboration is the cornerstone of every project at KCI Biotech. We work closely with partners to design customized studies, ensuring each experimental model precisely matches your research objectives. Contact us today to access expert consultation and translate your preclinical insights into clinical success.