Idiopathic pulmonary fibrosis

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease that is confined to the lungs and is prevalent in middle-aged and elderly people, with lung histology and/or high-resolution CT (HRCT) of the chest characterizing it as a generalized interstitial pneumonitis (UIP) of unknown etiology.With a mean survival of 2.8 years after diagnosis, and with a mortality rate higher than that of most tumors, IPF has been called a “tumor-like disease”. IPF has been called a “tumor-like disease”. We have established a stable model of idiopathic pulmonary fibrosis, which is suitable for preclinical studies of drugs for idiopathic pulmonary fibrosis and evaluation of new drugs.

Disease Name	Model name	Species of animals
Disease Name	Model name	Mouse	Rat	Hamster	Guinea pig	Ferret	Rabbit	Cat	Dog	Pig	Non-human primate
Idiopathic pulmonary fibrosis	Unilateral idiopathic pulmonary fibrosis model induced by a single bleomycin (BLM) dose		√
	Bilateral idiopathic pulmonary fibrosis model induced by a single bleomycin (BLM) dose	√	√
	Unilateral idiopathic pulmonary fibrosis model induced by repeatedly bleomycin (BLM) dose		√
	Bilateral idiopathic pulmonary fibrosis model induced by repeatedly bleomycin (BLM) do		√