CNS-Focused Preclinical CRO 

KCI Biotech is a preclinical neurology CRO dedicated to neurological drug discovery. Integrating deep neuroscience pharmacology expertise, our preclinical CRO CNS platforms provide reliable, GLP-compliant in vivo evaluations to accelerate translational success.

Why Use Animal Models in CNS Research

Because complex cognitive, motor, and blood-brain barrier pathways cannot be replicated in vitro, reliable CNS disease models are indispensable. Partnering with a dedicated preclinical neuroscience CRO provides the objective data, behavioral readouts, and controlled conditions required to bridge early research to clinical trials.

Our Portfolio of CNS Disease Models

KCI Biotech offers reproducible in vivo models for neurodegenerative, neurodevelopmental, and psychiatric indications:

Neurodegenerative Disease Models

• Alzheimer’s Disease: Validated alzheimer’s disease mouse models (APP/PS1, 5xFAD, 3xTg) alongside diet-induced and AAV9-htau-induced systems.
• Parkinson’s Disease: Comprehensive animal models of parkinson’s disease induced by 6-OHDA or MPTP in rodents and primates.

Neurodevelopmental & Neuropsychiatric Models

• Autism & Cerebral Palsy: Sodium valproate (VPA)-induced autism models and hypoxia-induced cerebral palsy models.
• Depression & Stroke: Validated depression models (CUMS) and acute stroke models, including the standard MCAO rat model.

Comprehensive CNS CRO Solutions & Collaboration

KCI Biotech delivers integrated preclinical solutions to de-risk neurological drug candidates:

Portfolio: The CNS CRO platform features a variety of specific CNS models within a library of 500+ validated disease models.

Facilities & Species: 18,000 m² AAALAC-accredited facilities supporting mice, rats, rabbits, dogs, and non-human primates.

Evaluation Platforms: Behavioral tracking (Morris Water Maze, Y Maze), 1.5T MRI/CT imaging, and neuropathology.

Track Record: Proven experience supporting 200+ IND filings (NMPA/FDA) for 1000+ global clients.

From stereotactic microinjection to PK/PD profiling, we provide end-to-end support for your preclinical pipeline. Contact our team today.