Pulmonary arterial hypertension

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Pulmonary Hypertension (PH) is a serious circulatory disease defined by alterations in the structure and/or function of the pulmonary vasculature caused by a variety of heterogeneous etiologies and different pathogenic mechanisms. As the disease progresses, persistently elevated pulmonary artery pressures increase the load on the right ventricle, the pump responsible for pumping blood into the lungs. Prolonged high load makes the right ventricle progressively hypertrophied and dilated, and eventually right heart failure may develop. We have established a stable model of MCT-induced pulmonary hypertension and a model of SU5416+ hypoxia-induced pulmonary hypertension, which are suitable for preclinical studies of drugs for atherosclerosis and evaluation of new drugs. If you have project needs and experience more of our professional services, please contact us.

Disease Name	Model name	Species of animals
Disease Name	Model name	Mouse	Rat	Hamster	Guinea pig	Ferret	Rabbit	Cat	Dog	Pig	Non-human primate
Pulmonary arterial hypertension	Deoxycorticosterone acetate (DOCA) + high salt-induced hypertension model		√
	Dahl salt-sensitive rat + high salt-induced hypertension model		√
	Model of hypertension induced by renal artery narrowing		√						√		√
	A model of hypertension induced by abdominal aortic constriction		√				√		√		√
	SHR rat spontaneous hypertension model		√
	High-fat feed-induced obesity hypertension model in dogs	√							√
	Model of L-NAME-induced hypertension		√