Platform

Reliable Cardiovascular Disease Models with Scientific Rigor and Reproducibility

KCI Biotech is a cardiovascular CRO providing comprehensive in vivo pharmacology and efficacy services. As a leading in vivo pharmacology CRO, we perform all experimental work under GLP-compliant management by professionally trained technical staff. Our capabilities are built to deliver scientific accuracy and reproducibility, supporting your pursuit of innovative therapies for cardiovascular and metabolic diseases.

Why Use Animal Models in Cardiovascular Research

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide. Because many pathological processes cannot be fully replicated in vitro, animal models of cardiovascular disease are indispensable tools for understanding disease mechanisms, evaluating drug efficacy, and predicting clinical outcomes.

At KCI Biotech, our cardiovascular disease models are carefully developed and validated to simulate human pathological conditions, enabling translational studies that bridge preclinical findings to clinical reality.

Our Portfolio of Cardiovascular Disease Models

KCI Biotech provides a wide spectrum of cardiovascular models that cover multiple disease mechanisms, including ischemic injury, heart failure, hypertension, atherosclerosis, and so on. Each model is established using reproducible induction methods and standardized evaluation criteria.

Stroke & Acute Myocardial Infarction Models

We offer various stroke and Acute myocardial infarction animal models:

• Permanent Ischemic Stroke Model
• Ischemia-Reperfusion Stroke Model
• Photochemically Induced Ischemic Stroke Model
• Collagenase-Induced Hemorrhagic Stroke Model
• Autologous thrombus-induced permanent ischemic stroke model
• Acute Ischemia-Reperfusion Myocardial Infarction Model
  Acute Permanent Ischemic Myocardial Infarction Model

Heart Failure Models

As a dedicated heart failure cro, we offer diverse animal models of heart failure:

• Heart Failure Induced by Myocardial Infarction
• Heart Failure Induced by Ascending Aortic Constriction (e.g., the TAC mouse model)
• Doxorubicin induced heart failure model
• Acetic deoxycorticosterone (DOCA)+high salt induced hypertension
• induced heart failure model
• Dahl salt sensitive rats+high salt induced hypertension induced heart failure model
• DIO mice – induced  heart failure model with preserved ejection fraction

Vascular Diseases

We provide reliable animal models of hypertension and animal models for atherosclerosis:

• Apoe-/- Mouse + Western Diet-Induced Atherosclerosis Model（APOE knockout mice）
• Atherosclerosis model induced by high-fat and high-cholesterol feed in rabbits and nonhuman primates
• Model of pulmonary arterial hypertension induced by wild larkspur (MCT)
• SU5416+ hypoxia-induced pulmonary hypertension model

Additional cardiovascular disease models are available upon request. Custom modeling and tailored evaluation endpoints can be provided based on sponsor needs.

Extensive Experience in Cardiovascular Pharmacology

As a cardiology CRO with a long-standing focus on cardiovascular research, KCI Biotech combines expertise in ischemic injury, heart failure, and vascular biology to support discovery and translational studies. Our team has deep experience with models for heart failure, atherosclerosis, hypertension, and myocardial infarction.

Extensive Capacity and Advanced Platforms

KCI Biotech has internationally advanced laboratory animal facilities certified by AAALAC in Suzhou and Nantong, with a total area of over 40,000m2 capabilities for meeting the needs of various preclinical experimental studies.，integrates in vivo imaging, biochemical, histopathological, and molecular analyses to evaluate therapeutic efficacy across multi-level endpoints. This ensures data reliability and high translational relevance.

Proven Partner for Global Pharmaceutical R&D

With over 1,000 domestic and international partnerships, KCI Biotech has established a strong reputation as a reliable CRO for cardiovascular trials. Our efficient communication, transparent data management, and rapid study turnaround make us a trusted partner for global clients.